| Introduction |
With the advent of the "omics" era metabolome and metabolomics are gaining more and more attention in order to understand the complexity of the underlying cellular networks in organisms. The completion of a long series of genomes has made the comparison of metabolic pathways possible.
Pathway Hunter Tool (PHT) is available via internet.
Features in Pathway Hunter Tool (PHT) via internet.
ChooseOne or more sequenced organisms or build your own virtual organism (Enzymes).
Local similarity: Similarity between substrate and product metabolite of a reaction.
Global similarity: Similarity between source and product metabolite after some reaction steps in a pathway.
Via Metabolites, not via Metabolites, via Enzymes, not via Enzymes.
Minimum number of steps, Maximum number of steps.
Organism-Reaction Matrix, Enzyme-Reaction Matrix and Genome Information Matrix.
Output: Information about enzyme, genes, motifs, disease information.
Graph: Directed (reversible and irreversible), Undirected (reversible).
 Arita M: The metabolic world of Escherichia coli is not small. Proc Natl Acad Sci U S A 2004, 101(6):1543-1547.
 Kanehisa M, Goto S, Kawashima S, Okuno Y, Hattori M: The KEGG resource for deciphering the genome. Nucleic Acids Res 2004, 32 Database issue:D277-280.
 Schomburg I, Chang A, Ebeling C, Gremse M, Heldt C, Huhn G, Schomburg D: BRENDA, the enzyme database: updates and major new developments. Nucleic Acids Res 2004, 32 Database issue:D431-433.
 Barabasi AL, Oltvai ZN: Network biology: understanding the cell's functional organization. Nat Rev Genet 2004, 5(2):101-113.
 yEd - JavaTM Graph Editor URL: http://www.yworks.com/.